Biology Services

ASBL - a Synonym to its Deliverables

Biology Services

ASBL is located strategically in Hyderabad to help us serve our clients and deliver the best expertise effectively and efficiently. ASBL is an organization providing end-to-end Pre-clinical services with superior performance, interpretation, review, and reporting deliverables. Our business models are flexible enough and have evolved with the time to accommodate our clients’ requirements as each research program or project is highly time sensitive and must be delivered on schedule and of the highest quality. ASBLs’ infrastructure, standard operating procedures and the scientific pool is able to ensure our clients for consistent, uniform, and standardized practices for every service offering.      

  • Physicochemical Properties

          - Aqueous Solubility in PBS (pH 7.4), SGF and SIF
          - Partition coefficient (log D) using n-octanol/PBS (pH 7.4)

  • Metabolic Stability

          - Intrinsic Clearance using Liver Microsomes (Human, Rat, Mouse, Dog, Monkey)
          - Intrinsic Clearance using Cryopreserved Hepatocytes (Human, Rat, Mouse, Dog, Monkey)

  • Metabolite Identification using Liver Microsomes (Human, Rat, Mouse, Dog, Monkey)
  • CYP Inhibition and CYP Induction
  • P-gp Inhibition using MDR1-MDCK II cell line
  • Plasma Protein Binding (Human, Rat, Mouse, Dog)
  • Blood and Plasma Stability (Human, Rat, Mouse, Dog)
  • Blood Partitioning (Human, Rat, Mouse, Dog)
  • Single/Multiple Dose pharmacokinetics

         - Support Bioavailability/ Bio-equivalence Studies

  • Standardized Surgical Techniques

- Single/ Double Cannulation of vessels used in in vivo ADME studies for sample collection as well as for administration/infusion

  • Routes of administration 

- Per oral, Intravenous (bolus/infusion), Intraperitoneal, Subcutaneous, Intramuscular, Intra-dermal, Topical, Ocular, Inta-tracheal, Intranasal (liquid/powder), Intra-urinary bladder 

  • Tissue distribution studies 

- Blood Brain Barrier studies, Generalized Tissue Distribution, Localized like ocular Tissue Distribution studies

  • PK/PD relationship studies

- To link pharmacokinetics and pharmacodynamics in order to establish and evaluate dose-concentration-response relationships and subsequently describe and predict the effect-time courses resulting from a drug dose

  • Species

- Rat, Mice, Guinea Pig, Hamster, Rabbit, Dog

Animal models are powerful tools to assess the efficacy, mechanism of action and safety profile of compounds. This data form an essential part of the preclinical drug discovery and preclinical drug development processes. 
To develop an animal model, ASBL’s experienced team works as an independent extension of your pre-clinical program. Combining pharmacokinetic capabilities of ASBL with the efficacy model will give you an insight of the PK/PD correlation for the molecule at early stage of the drug development. ASBL specializes in preclinical efficacy studies in rodent models of various therapeutic areas.

  • Metabolic Disorders
  • Central Nervous System
  • Pain and Inflammation
  • Gastrointestinal System
  • Ophthalmic Screening

We, at ASBL, are adaptable and flexible enough, and our experienced team will work with you to design and develop a model tailored to suit your specific project requirement.

  • Maximum Tolerated Dose (MTD)
  • Dose Range Finding (DRF)
  • Acute, Sub acute and Chronic Toxicity with Toxicokinetics
  • AMES Assay
  • In vitro Genotoxicity
  • Cytotoxicity
  • Biologics/ Vaccines - Batch Release Testing 

         - Potency Assay – In vivo and In vitro
         - Abnormal Toxicity Test (ATT)
         - Pyrogen Test
         - Cytotoxicity - ADCC and CDC

  • Tests for Bio-similars

         - Erythropoietin Bioassay
         - Insulin Assay
         - Sodium Heparin Assay

  • Biocompatibility Studies as per ISO 10993 and USP

         - Skin / Eye Irritation Test
         - Mucus Membrane Irritation Test
         - Intracutaneous Irritation Test
         - Dermal Sensitization Test
         - Implantation Tests
         - Systemic Toxicity Test
         - Hemolysis Test

  • GLP services 

         - Strategic collaboration with the GLP and AAALAC accredited facility
         - Toxicity Studies – Acute, Sub-acute and Reproductive Toxicity
         - Mutagenicity Studies – Micronucleus Assay and AMES Test

  • Monoclonal and Polyclonal Antibody Production

WE DELIVER SCIENCE USING BIOLOGY

Every Client admires our Deliverables